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The absence of such gating in front of the active sites for SSCs, particularly for clade 3 catalases (which includes multicellular animals) might suggest that H 2 O 2 production levels in the intracellular milieu of faster metabolising creatures are large enough to ensure enough H 2 O 2 molecules will always reach the active site in time to react with the Compound 1 intermediate before it can inactivate the enzyme